Table 5 Association of the DCC rs2229080 variant with clinicopathological characteristics

Age (years)

  < 50

13/14

9/17

6/13

0.49 (0.14–1.69); 0.412

0.57 (0.18–1.72); 0.471

0.46 (0.17–1.26); 0.131

  > 50

35/64

119/87

50/37

0.84 (0.29–2.41); 0.957

2.50 (1.52–4.10); 0.001

2.28 (1.40–3.72); 0.001

Sex

 Male

26/43

75/48

33/18

3.03 (1.42–6.43); 0.006

2.58 (1.40–4.74); 0.002

2.70 (1.52–4.81); 0.001

 Female

22/35

53/56

23/32

1.14 (0.53–2.43); 0.876

1.50 (0.78–2.89); 0.217

1.37 (0.74–2.54); 0.390

TNM stage

 I + II

16/78

33/104

20/50

1.95 (0.92–4.11); 0.114

1.54 (0.79–3.00); 0.259

1.67 (0.90–3.12); 0.135

 III + IV

28/78

95/104

36/50

2.00 (1.09–3.68); 0.035

2.54 (1.52–4.25); 0.001

2.36 (1.45–3.87); 0.001

Localization

 Colon

21/78

61/104

25/50

1.76 (0.89–3.48); 0.143

2.06 (1.15–3.68); 0.019

1.96 (1.13–3.41); 0.021

 Rectum

26/78

67/104

31/50

1.86 (0.98–3.49); 0.075

1.93 (1.12–3.31); 0.022

1.90 (1.14–3.18); 0.017